Gu Chaochao was murdered by his husband Zhou Junlan and his best friend Qiu Xianer on the wedding night, and he fell off the cliff with the infamy of elopement.Zhou Junlan forged a reputation of benevolence and righteousness and married Qiu Xian'er, and became a powerful minister with the support of the Gu family, while Qiu Xian'er helped her rise to the top with her golden fingers.

Five years later, Gu Chaochao transformed into Ji Yunchao, the daughter of the Medicine King Valley. She set up a situation to discord Zhou and Qiu, resolved her murderous intent and backed on her opponents, endured for five years, and finally played with her enemies with her wisdom, paving the way to revenge.